Key details
Dr Simon C W Richardson
Reader of Drug Delivery and Membrane Trafficking
Dr Richardson is the co-founder of the Exogenix laboratory and inventor of the Anthragenix and Exogenix delivery platforms. Dr Richardson undertook his PhD at The Centre for Polymer Therapeutics at the UCL School of Pharmacy, reading the intracellular delivery of ASOs. Following this he became a post-doctoral fellow at the Department of Molecular Physiology and Biophysics at the University of Iowa, where he studied the molecular regulation of endocytic vesicle fusion.
Dr Richardson was later appointed a Visiting Assistant Professor at the Department of Anatomy and Cell Biology at the University of Iowa, where he initiated his own research program investigating the use of protein toxins as drug delivery tools. This research focus followed him back to the 秋葵视频, where he is now Reader in Drug Delivery and Membrane Trafficking and runs the Exogenix lab.
Responsibilities within the university
- Chair of the University Biological and Genetic Modification Safety Committee
- University Biological Safety Officer
- Chair of the Faculty of E-S Research Ethics Committee
- Faculty Research Ethics Committee representative to the University Research Ethics Committee
- Faculty Research and Enterprise Committee.
Recognition
Affiliations
- Controlled Release Society (USA): Member
- American Society of Cell Biology: Member
- Society of Biology (UK): Member (MSB), Chartered Biologist (CBiol)
- Cardiff Institute of Tissue Engineering and Repair: Member
- Academy of Pharmaceutical Sciences: Member
- Oligonucleotide Therapeutic Society: Member
Editorial boards
Molecular and Clinical Pharmacology, Cogent Chemistry and Cognate Medicine, The Journal of Pharmaceutics (2012-2017). I am currently part of a team of the academics acting as guest editors for a special edition of The Journal of Drug Targeting. In 2015 I was a Journal of Controlled Release "Recognised Reviewer" and "Outstanding Reviewer".
Reviewer for: The Welcome Trust; The BBSRC; The Royal Pharmaceutical Society; BigC; The Journal of Controlled Release (Outstanding Reviewer); The Journal of Drug Targeting; Biomacromolicules and Biomaterials.
Research / Scholarly interests
Small inhibitory (si) RNA has the potential to cure viral conditions such as those caused by SARS-CoV-2 however to be effective this new type of drug needs to be able to get into the correct part of the cell. This is difficult because cells have evolved to stop this from happening. My lab focuses on the use of de-toxified toxins to deliver siRNA and more recently the gene editing protein Cas9. We do this directly using toxins (Anthragenix delivery) or by packaging the drugs into nanoscale vesicles called exosomes (Exogenix delivery) in an attempt to unlock the anti-viral potential of these molecules.
Recent publications
Article
Coakley-Youngs, Emma , Ranatunga, Medhavi, Richardson, Simon, Getti, Giulia , Shorter, Susan , Fivaz, Marc (2022), . The Company of Biologists. In: , , , . The Company of Biologists, Biology Open, 11: bio058941 (9) . pp. 1-11 2046-6390 (Online) (doi: https://doi.org/10.1242/bio.058941).
Feron, Benedita and , Richardson, Simon (2022), . Library Publishing Media. In: , , , . Library Publishing Media, European Journal of Extracellular Vesicles, 2 . pp. 1-14 ISSN: 2001-3078 (Print), (doi: http://libpubmedia.co.uk/wp-content/uploads/2022/02/Feron.pdf).
Ranatunga, Medhavi , Rai, Rajeev, Richardson, Simon C. W., Dyer, Paul , Harbige, Laurence , Deacon, Andrew , Pecorino, Lauren , Getti, Giulia T. M. (2019), . Wiley. In: , , , . Wiley, The FEBS Journal (Federation of European Biochemical Societies), 287 (9) . pp. 1777-1797 ISSN: 1742-464X (Print), 1742-4658 (Online) (doi: https://doi.org/10.1111/febs.15166).
Feron, Benedita Ka莽 Labb茅 and , Richardson, Simon Clifford Wainwright (2018), . Bentham Science Publishers. In: , , , . Bentham Science Publishers, Drug Delivery Letters, 9 (1) . pp. 79-88 ISSN: 2210-3031 (Print), 2210-304X (Online) (doi: https://doi.org/10.2174/2210303109666181224115722).
Satchi-Fainaro, Ronit , Vicent, Maria, Richardson, Simon (2017), . Taylor & Francis. In: , , , . Taylor & Francis, Journal of Drug Targeting, 25 (9-10) . pp. 757-758 ISSN: 1061-186X (Print), 1029-2330 (Online) (doi: https://doi.org/10.1080/1061186X.2017.1371722).
Ghosh, Saptarshi , Bouvaine, Sophie, Richardson, Simon C. W., Ghanim, Murad , Maruthi, M.N. (2017), . Springer Verlag. In: , , , . Springer Verlag, Journal of Pest Science, 91 . pp. 17-28 ISSN: 1612-4758 (Print), 1612-4766 (Online) (doi: https://doi.org/10.1007/s10340-017-0910-8).
Shorter, Susan , Pettit, Marie W., Dyer, Paul D.R., Coakley-Youngs, J. Emma , Gorringe-Pattrick, Monique A. M. , El-Daher, Samer , Richardson, Simon (2017), . Taylor & Francis. In: , , , . Taylor & Francis, Journal of Drug Targeting, 25 (9-10) . pp. 809-817 ISSN: 1061-186X (Print), 1029-2330 (Online) (doi: https://doi.org/10.1080/1061186X.2017.1358725).
Rai, Rajeev , Dyer, Paul, Richardson, Simon, Harbige, Laurence , Getti, Giulia (2017), . Cambridge University Press. In: , , , . Cambridge University Press, Parasitology, 144 (14) . pp. 1912-1921 ISSN: 0031-1820 (Print), 1469-8161 (Online) (doi: https://doi.org/10.1017/S0031182017001366).
Shorter, Susan , Gollings, Alexander, Gorringe-Pattrick, Monique, Coakley, Emma , Dyer, Paul D.R. , Richardson, Simon (2016), . Taylor & Francis. In: , , , . Taylor & Francis, Expert Opinion on Drug Delivery, 14 (5) . pp. 685-696 ISSN: 1742-5247 (Print), 1744-7593 (Online) (doi: http://dx.doi.org/10.1080/17425247.2016.1227781).
Mohsen, R. , Alexander, B. D., Richardson, S. C. W., Mitchell, J. C. , Diab, A. A. , Snowden, M. J. (2016), . OMICS International. In: , , , . OMICS International, Journal of Nanomedicine and Nanotechnology, 7: 1000363 (2) . pp. 363-372 ISSN: 2157-7439 (Print), (doi: http://dx.doi.org/10.4172/2157-7439.1000363).
Dyer, Paul D. R. , Kotha, Arun K., Gollings, Alex S., Shorter, Susan A. , Shepherd, Thomas R. , Pettit, Marie W. , Alexander, Bruce D. , Getti, Giulia T. M. , El-Daher, Samer , Baillie, Les (2016), . Elsevier. In: , , , . Elsevier, Biochimica et Biophysica Acta (BBA) - General 秋葵视频, 1860 (7) . pp. 1541-1550 ISSN: 0304-4165 (Print), (doi: https://doi.org/10.1016/j.bbagen.2016.03.024).